全文获取类型
收费全文 | 1757篇 |
免费 | 186篇 |
国内免费 | 297篇 |
专业分类
化学 | 1224篇 |
晶体学 | 20篇 |
力学 | 73篇 |
综合类 | 5篇 |
数学 | 186篇 |
物理学 | 732篇 |
出版年
2024年 | 1篇 |
2023年 | 116篇 |
2022年 | 64篇 |
2021年 | 51篇 |
2020年 | 158篇 |
2019年 | 71篇 |
2018年 | 73篇 |
2017年 | 91篇 |
2016年 | 100篇 |
2015年 | 93篇 |
2014年 | 142篇 |
2013年 | 114篇 |
2012年 | 133篇 |
2011年 | 102篇 |
2010年 | 105篇 |
2009年 | 132篇 |
2008年 | 63篇 |
2007年 | 87篇 |
2006年 | 111篇 |
2005年 | 58篇 |
2004年 | 43篇 |
2003年 | 62篇 |
2002年 | 51篇 |
2001年 | 54篇 |
2000年 | 27篇 |
1999年 | 64篇 |
1998年 | 31篇 |
1997年 | 6篇 |
1996年 | 5篇 |
1995年 | 9篇 |
1994年 | 5篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 3篇 |
排序方式: 共有2240条查询结果,搜索用时 15 毫秒
51.
药物种类按照分子量来划分可以分为小分子药物(自然提取或化学合成的)和大分子药物(生物制剂). 尽管目前小分子药物仍然是市场的主流, 但其研发增速趋缓, 而大分子药物在药物研发中的地位日渐突显, 并被预期在未来药物市场中占据越来越高的份额. 除了生物制剂大分子药物, 将小分子药物与天然或合成大分子结合制备得到的化学合成大分子药物, 近年来受到药物研究者们越来越多的关注. 由于大分子具有丰富的骨架结构及空间构架, 其所特有的骨架效应、多价效应, 以及通过分子组装而产生的聚集效应和靶向效应等, 能够为药物化学的设计带来更多新的可能. 有鉴于此, 本综述将简略介绍药物化学设计中的大分子效应, 重点讨论合成大分子的骨架效应、多价效应、聚集效应和靶向效应等为药物化学设计所带来的新性能. 通过对药物化学中大分子效应所带来的优势、问题和重要研究进展的探讨, 以期能够推动化学合成大分子药物的发展, 为药物化学设计提供新的思路. 相似文献
52.
摩托车传动用滚子链磨损特性的研究 总被引:5,自引:1,他引:5
道路行驶磨损试验结果表明,摩托车传动用滚子链套筒和销轴零件的主要磨损形式是磨粒磨损,并伴随有疲劳磨损的特征.由微观分析和链条的磨损伸长量可知:套筒和销轴的初始表面硬度较高,有利于改善其磨损表面形貌状态和耐磨性;在磨粒磨损机制下,套筒和销轴零件的表面硬度较低,容易产生“犁切”,表面层的循环硬化现象比较明显,磨损严重;在油池润滑条件下,套筒和销轴零件的表面硬度较高,裂纹的扩展速率较快,循环软化现象也较明显,当表面硬度较低时发生循环硬化.循环软化与循环硬化是导致磨损严重的原因之一. 相似文献
53.
54.
55.
Zhang D. W. Teng J. H. Mu S. J. Li Hong 《International Journal of Theoretical Physics》2021,60(4):1539-1549
International Journal of Theoretical Physics - A scheme is proposed for preparing Greenberger-Horne-Zeilinger (GHZ) states by Lyapunov control based on quantum Zeno dynamics. The advantage of our... 相似文献
56.
Coil-rod-coil molecules 1–3, consisting of four biphenyls and a p-terphenyl unit linked together with ether bonds as a rod segment and poly(propylene oxide) (PPO) with a degree of polymerization (DP) of 7, 12, 17 as coil segments were synthesized. These molecules contain lateral methyl groups at 2 and 5 positions of the middle benzene ring of p-terphenyl. The self-assembling behavior of molecules 1–3 was investigated by means of DSC, POM and SAXS in the bulk state. Molecule 1 self-organizes into a lamellar structure in the bulk state and transfers into a bicontinuous cubic structure in the liquid crystalline phase. While, molecules 2, 3 containing longer coil chains than 1 self-assemble into the hexagonal perforated lamellar (HPL) structures and the oblique columnar structures in the solid state and liquid crystalline phase, respectively. These results reveal that self-organizing behavior of such molecules is dramatically influenced by the length of the coil chains connected with the rod building block, as well as the lateral methyl groups incorporating in the middle of the rod segment. 相似文献
57.
Two new spirostanol saponins, namely elephanosides G and H ( 1 and 2 , resp.) were isolated from the leaves of Yucca elephantipes (Agavaceae), together with the two known furostanol saponins 3 and 4 and the six known flavonoid O‐ and C‐glycosides 5 – 10 . The new structures were elucidated as (3β,25S)‐spirost‐5‐en‐3‐yl O‐β‐D ‐glucopyranosyl‐(1→3)‐O‐β‐D ‐glucopyranosyl‐(1→4)‐β‐D ‐galactopyranoside ( 1 ) and (3β,5β,25R)‐3‐[(2‐O‐β‐D ‐glucopyranosyl‐β‐D ‐galactopyranosyl)oxy]spirostan‐12‐one ( 2 ) on the basis of detailed spectroscopic analysis and acidic hydrolysis. 相似文献
59.
《Tetrahedron》2019,75(38):130514
This study presents the synthesis, characterization, and electrochemical properties of four new dialkoxymethanofullerenes, as well as their performance in organic solar cells (OSCs) devices. Dialkoxymethanofullerenes were synthesized in 27%–32% yield by thermolysis of dialkoxyoxadiazolines and reaction with C60 under reflux in toluene. The prepared compounds were then characterized and used for the first time as electron-acceptor materials in thin-film bulk heterojunction OSCs with PBTZT-stat-BDTT-8 as the electron donor material. The devices made with ethoxy-hexyloxymethanofullerene and methoxy-hexyloxymethanofullerene exhibited optimal power conversion efficiencies (PCEs) of 3.79% and 4.65%, with open-circuit voltage of 0.832 and 0.831 V, respectively. In contrast, the devices made with ethoxy-ethoxymethanofullerene and methoxy-ethoxymethanofullerene exhibited very low PCEs of <0.01% for both, indicating a large impact of the substituents on device performance. 相似文献
60.
Mengmeng Ma Ying Wang Nan Gao Xinping Liu Yuhuan Sun Prof. Jinsong Ren Prof. Dr. Xiaogang Qu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(51):11852-11858
Proteolysis of amyloid-β (Aβ) is a promising approach against Alzheimer's disease. However, it is not feasible to employ natural hydrolases directly because of their cumbersome preparation and purification, poor stability, and hazardous immunogenicity. Therefore, artificial enzymes have been developed as potential alternatives to natural hydrolases. Since specific cleavage sites of Aβ are usually embedded inside the β-sheet structures that restrict access by artificial enzymes, this strongly hinders their efficiency for practical applications. Herein, we construct a NIR (near-IR) controllable artificial metalloprotease (MoS2-Co) using a molybdenum disulfide nanosheet (MoS2) and a cobalt complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Codota). Evidenced by detailed experimental and theoretical studies, the NIR-enhanced MoS2-Co can circumvent the restriction by simultaneously inhibition of β-sheet formation and destroying β-sheet structures of the preformed Aβ aggregates in living cell. Furthermore, our designed MoS2-Co is an easy to graft Aβ-target agent that prevents misdirected or undesirable hydrolysis reactions, and has been demonstrated to cross the blood brain barrier. This method can be adapted for hydrolysis of other kinds of amyloids. 相似文献